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Danazol as a drug used for endometriosis treatment DANAZOL AS A DRUG USED FOR ENDOMETRIOSIS TREATMENT
How Danazol works
It is thought that Danazol eradicates endometrial implants in several ways. The net result is that the production of oestrogen is suppressed and the levels of oestrogen in the body decrease to the low levels found in women following the menopause. Hence, Danazol treatment is sometimes referred to as pseudo-menopausal treatment because it mimics the hormonal condition of menopause.
The low levels of oestrogen mean that the endometrial implants are no longer stimulated to grow and break-down each month. Therefore, they become inactive and begin to gradually waste away.
Ovulation and menstruation usually cease by the end of the second month of treatment though this may depend on the dosage being taken. The symptoms of endometriosis usually begin to decrease by the end of the second month of treatment and then continue to improve throughout the course of treatment.
Dosages of Danazol generally used
The dosage and length of your treatment will depend on a variety of factors including the severity of your disease, your response to the treatment and your gynecologist’s preferences.
Most gynecologists recommend that you start with a dosage of 600 to 800 milligrams per day (three or four 200 milligram capsules per day). Some research studies have suggested that Danazol is equally effective at lower dosages if your periods are suppressed. Your gynecologist may decrease your dosage to 600 milligrams or even 400 milligrams per day once your periods have stopped.
In order to increase the effectiveness of the drug it is best to take the capsules at fairly evenly spaced times throughout the day — in other words one capsule every eight hours if you are on 600 milligrams per day or every six hours if you are on 800 milligrams per day.
The usual length of a course of treatment with Danazol is three to nine months — the average length being about six months. A further course of Danazol may be used if you have a recurrence of your endometriosis as there is no evidence to suggest that the implants become resistant to the drug. Because so little is known about the effects of repeated or long-term use of Danazol you should probably only have two or three courses in your lifetime and you should not have a prolonged course of treatment beyond twelve months.
You should start your course of Danazol on the first day of your period to minimize the likelihood of taking the drug while you are pregnant. If you do not begin the treatment at the start of a period you should have a pregnancy test to make sure that you are not pregnant.
Although it is unlikely that you will conceive during your course of treatment with Danazol every care should still be taken to avoid pregnancy. The manufacturers of Danazol recommend that some form of barrier contraception (e.g. condom or diaphragm) be used while taking the drug, particularly during the first two months of treatment or if you are taking less than 800 milligrams per day. The oral contraceptive (the Pill) should not be taken at the same time as Danazol.
You should see your gynecologist about six to eight weeks after beginning your course of Danazol to discuss how the treatment is progressing and any problems that you may be having. Thereafter, you should see him or her every two to three months for the remainder of your course of Danazol.
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